It's a landmark day in my career as I take on a new responsibility
@JAMA_current
- a beacon of practice & policy-defining science for 140 yrs
Honored & excited to work w
@KBibbinsDomingo
& Editors, & privileged to support rigorous transformative science in
#AI
#ML
#DigitalHealth
This month we welcome
@rohan_khera
as a JAMA Associate Editor. Dr Khera is an Assistant Professor of Medicine in the Section of Cardiovascular Medicine at
@YaleMed
, and of Biostatistics in the Section on Health Informatics at the
@YaleSPH
.
This was always the inevitable end of pseudo intellectualism & fad based medicine of our times.
Celebrities making proclamations about untested treatments during a public health emergency.
These are scary times.
#coronavirus
#Hydroxychloriquine
@elonmusk
Worrying preprint:
#SARSCoV2
RNA detected in ~66% of *air samples* - collected inside pt rooms & hallways. + on all surfaces. Patients w/o cough/fever. Adds to last wk's
@NEJM
study
Risk in:
- Healthcare workers NOT directly caring for
#COVID19
- People in enclosed public spaces
What a scary sight to see a player collapse on live TV from what seemed like a cardiac arrest.
Prayers for Damar Hamlin - if it was Commotio Cordis - a fatal arrhythmia triggered by chest trauma at a specific time in cardiac cycle, hopefully timely CPR will improve outcome
A weird time to start your first real job, but thankful to family, mentors & friends for all the fun times over the past 14 years spent in medical training.
Excited to start the next chapter on the faculty
@YaleMed
@YaleCardiology
today.
Mask off only for the photo.
A glorious day for Cardiology!
@hmkyale
will take on the helm as the next EIC
@JACCJournals
!
Anyone who knows Harlan knows it’s going to be transformative for cardiology & scientific publishing
It’s been an honor to have had him as a mentor & friend over the years! Can’t wait!
Faculty at major institutions receive many many research opportunity requests daily/weekly.
From local/regional/international students & graduates
This IS THE pool for recruiting ⭐️s but very few such email reach outs are effective
My suggestions on making these emails work:
Grateful to the
@nih_nhlbi
for their support of my research focusing on improving evidence-based care for patients w/ heart failure.
Excited to leverage informatics, NLP & machine learning to better understand & improve care processes
@YaleMed
Thx,
@hmkyale
@ericjvelazquez
In
@CircAHA
, our study demonstrates the ability to identify LV Systolic Dysfunction on *images* of ECGs.
Potential for
#AI
-based accessible screening in practice ()
Massive effort, led by
@Veer_Sangha_
@ArashNargesi
@cards_lab
Our tool to detect ATTR Amyloid Cardiomyopathy from ECG images - ECGvision-ATTR - has received
@US_FDA
Breakthrough Device Designation!
A key milestone for our science from
@cards_lab
, led by
@Veer_Sangha_
, moving closer to clinical care through
@Yale
-backed
@ensight_ai
Thanks
Nothing -absolutely nothing- prepares women in medicine for arguably their toughest time in life. Instead our culture ensures it's a battle against feelings of inadequacy and self-doubt.
A difficult piece from my better half,
@snigdhajain89
#HeForShe
Thanks,
@nytimes
for honoring a healthcare hero. It’s heartbreaking.
Would’ve been great to refer to her as “Dr.” Madhvi Aya here though
An international medical graduate doesnt lose their title practicing in a different role in the US
#respect
#Healer
Finally the
#NOA
, &
@cards_lab
officially has its 1st R01-funded program - our Evidence Innovation Program
We are building upon our foundations of AI/ML for clinical trial inference - and are working to develop rigorous standards and methods to enable reliable learning &
Congratulations to
@ekoikonomou
- winner of the Elizabeth Barrett-Connor Award 2023 at
#AHA23
for his work on adaptive predictive enrichment of randomized clinical trials with machine learning!
Such an honor that
@cards_lab
members got this 2 years in a row!
@YaleCardiology
What a cool thing to walk home to - thanks so much,
@girish_nadkarni
! Really appreciate all your support, guidance & friendship.
#firstR01
- also big shout out to the amazing team
@cards_lab
In
#AI
for medicine, we often hear, "Oh, this tool just assists clinicians - they decide care"
In
@JAMA_current
,
@SarahJabbour_
et al's randomized study finds potential harm from decision support w assistive AI
We cover "Automation Bias" in an editorial
Can AI/ML help make randomized clinical trials (RCTs) smaller & faster?
In
@npjDigitalMed
, led by
@ekoikonomou
@cards_lab
we present a novel, fully-automated, predictive enrichment strategy for RCTs
Using computational phenomapping in interim analyses
📣This deserves a special shout out
#AHA23
:
@cards_lab
fellow
@AryaAminorroaya
wins 2nd place for the Lp(a) data analysis challenge - a $25K prize for innovation in optimizing efficient Lp(a) testing - clear value of new ML-based approach - ARISE - deployed in EHRs. So proud!
It's almost time for
#AHA23
- proud of the amazing team
@cards_lab
for their strong showing
Please come say hi! We'll be sharing session details shortly
@YaleMed
@Yale
Yesterday, I learned that another team member
@Yale
will be returning to their home country.
The apathy towards immigrants not seeing families due to arbitrary restrictions threatens US leadership in innovation for years to come. My thoughts on
@Medium
.
The ASCI is proud to announce our 2024 Early-Career Awardees!
Click here for the complete list of awardees:
YPSA:
E-Gen:
Congratulations to our awardees and to the institutions they represent!
Excited to share
@cards_lab
's 1st
@AppStore
iOS entry - CarDS-Plus 📲
What is special about this App? Why did a research lab need one?
I have shared before how
@cards_lab
has developed AI models to detect various cardiomyopathies on smartwatch⌚️ & portable ECGs ⚡️ (link in
Immensely grateful for our
@cards_lab
family and beautiful Connecticut days spent together.
What a privilege and blessing to live this dream
@Yale
@YaleMed
In
@NatureComms
, led by
@Veer_Sangha_
@cards_lab
is our deep learning approach to layout-free automated clinical diagnosis & hidden label detection from ECG images
With broad global access to ECG images, this represents an advance for AI in ECG inference
Great to finally meet pathbreaking
@aiims_newdelhi
alumnus
@Aiims1742
- Dr. Anirban Maitra from
@MDAndersonNews
On the left is proud Aiims2561.
Thanks to
@the_asci
for the venue, and congrats to Dr. Maitra for your induction into the ASCI!
Out in
@NatureCVR
, led by
@AryaAminorroaya
@cards_lab
, is an
#ML
tool to make Lp(a) testing more efficient - ARISE
⬆️Lp(a) is an atherosclerotic risk marker w therapies on the horizon, but testing is ⬇️⬇️
ARISE can reduce number-needed-to-test ~50%
🧵👇🏽
Our
@JAMA_current
study on issues with research quality using
#NIS
. 85% of studies violated >=1 required practices. Onus on us to improve & realize the potential of
#DataSharing
Appreciate the mentorship
@hmkyale
!
Potentially practice changing study in
@NEJM
today. The original TTM trial made it less onerous to treat cardiac arrest survivors by making mild hypothermia the standard, and with TTM2, it is likely that preventing fever alone may be enough.
#RCTsFTW
If you are
@ACCinTouch
#ACC24
, please come say hi to our incredible team
@cards_lab
We are presenting our work on
Digital biomarkers
RCT digital twins
AI-powered diagnostics (ECG/echo/wearables) Multinational federated CES
+ more
@YaleCardiology
🔗
I appreciated the opportunity to contribute to the American Heart Association's Centennial collection.
Also, to think about AI in cardiovascular care, now & in the future, with brilliant colleague Jenna Wiens
@UMich
Out in
@CircOutcomes
:
@cards_lab
A great read by
@deevybee
in
@nature
. The epidemic of flawed "science".
4 practices should be reined in soon:
1) publication bias
2) low statistical power
3) P-value hacking
4) HARKing (hypothesizing after results known)
#1
and
#4
bane of
#outcomes
#healthpolicy
research
Typically don't tweet at this frequency but we're on a roll here at
#AHA21
!
@ekoikonomou
@cards_lab
@YaleCardiology
is the winner of the Lifestyle and Cardiometabolic Health YIA! So proud of him & our group
Precision care Rx strategies for hypertension through
#MachineLearning
Such an awesome feeling to have
@ekoikonomou
’s F32 funded - feels way better than many personal accomplishments
Congrats to a brilliant, creative and kind physician-scientist.
Privileged to get to work with you!
#ProudMentor
@cards_lab
@YaleCardiology
Thrilled to receive the
#NOA
for my
#F32
today.
Grateful to
@nih_nhlbi
for funding and all mentors for their support.
Looking forward to applying
#AI
for multi-modal point-of-care screening of CV disease and working with the amazing team
@cards_lab
@Yale
led by
@rohan_khera
.
Excited to share the preprint for our
#DeepLearning
tool that detects LV systolic dysfunction from ECG images, independent of their format
@cards_lab
Represents our ongoing effort to make application of
#AI
driven advanced ECG inference accessible
#ML
Thanks to
@UTSWNews
@UTSWCardfellow
for being the most amazing place to spend the last 4 years.
Despite the virtual-ness of the graduation, the awesome-ness of the place doesn’t cease to amaze. Thanks for the great gesture and the presents too,
@GailPetersonMD
@dramitkhera
Dear graduates- our virtual graduation isn’t enough- had to see you 1 more time! We are proud of you and miss you already. Looking forward to seeing your highly successful careers!
My memoir will probably be titled, “My struggles with a tiny electric snowblower”. Oh did I underestimate the Northeast snowstorms.
#rookie
#beautifulthough
An overdue update from
#AHA23
is
@aakhunte
's (
@cards_lab
&
@Yale
'24) amazing work on improving access to ECG Diagnostics for 🌎
The preprint will be up soon, but a link to our ambitious
#ECG_GPT
project:
ECG Photo 📸 --> ECG read to allow patient
In
@JAMAInternalMed
is our evaluation of revascularization practices in AMI w shock
In 2017, CULPRIT-SHOCK found harm w MV-PCI in MV-CAD - in the decade preceding it, MV-PCI was an increasingly popular strategy.
🧵below
w/
@rwyeh
@ACCinTouch
Congratulations to Yale’s five 2023 Rhodes Scholars!
Sophie M. Huttner, Henry Large, James A. (JT) Mullins, Ulystean J. (Jonathan) Oates, and Veer Sangha, all from the Class of 2023, were among 32 U.S. winners named over the weekend. Full story to come on Yale News.
#Yale
Led by ⭐️
@Yale
senior,
@cards_lab
member & future physician-scientist
@aakhunte
, our study in
@npjDigitalMed
demonstrates detection of LV systolic dysfunction on noisy single-lead ECGs, now on many watches/devices w major implications for screening
We have NOT done a good job if more die this year from mishandling a disease than military deaths in World War I. And it's also not acceptable if we're on course to rivaling World War II deaths. This is so very sad.🙁
#coronavirus
#StayHome
#COVID19
Fantastic presentation by
@AryaAminorroaya
@cards_lab
fellow for Quest Diagnostics & Steve Rusckowski YIA for Preventive CV Medicine Research
#aha23
He developed & performed multinational validation of ARISE - a novel ML tool to ⬆️ efficiency of Lp(a) testing
Web app+preprint👇🏽
This 👇🏼 - injecting lethal carcinogens into lungs - as Rx suggestion from US leadership - clinches the spot for most depressing thing today
Could’ve been failed remdisivir RCT
OR
Only 21% sampled NYC residents being antibody +ve for
#COVID19
in a city already overwhelmed by it
Predictably, practice-changing science being presented at
@escardio
#ESC2023
With STEP-HFpEF - GLP1-RAs, now a therapy for HFpEF
Once weekly semaglutide for HFpEF presented by
@MkosiborodMD
& published in
@NEJM
. Congrats to investigators & patients
Our
@JAMACardio
study on financial toxicity from out-of-pocket costs in ASCVD care. 2 million low-income US families at risk for financial ruin every year, incl those w insurance. Winning battle with new Rx but losing the war on ASCVD
@khurramn1
@hmkyale
Despite the ⬆️ availability of smart⌚️& other remote monitoring devices, their healthcare integration + healthcare impact is limited.
In our
@AHAScience
Scientific Statement, we address the strategies - technical & clinical - to bridge this gap
🔗
120 Million followers & the full force of boosting up by Twitter’s algorithms. To target one public service official. And mock a respect for gender identity. Just great! Why??
The
@cards_lab
is growing. We're recruiting for many roles:
(1) Clinical postdoctoral fellow
(2) Computational postdoctoral fellow
(3) Data Scientist
(4) Program Coordinator
Find out more here:
🔗
Please share with your network!
@YaleMed
@Yale
Proud of
@cards_lab
members, showcasing our science at
#AHA22
@AHAMeetings
- spanning innovations in:
- AI-enhanced adaptive RCT designs
- precision medicine
- strategies to translate discoveries from RCTs to EHRs
- accessibility of technology and care
Texas is getting hit hard with rising COVID19 hospitalizations.🙁
Pretty unfortunate that the sole focus is on maintaining healthcare capacity by canceling procedures, w/o public health measures to prevent spread (open bars/restaurants, no masking policy)
Join
@cards_lab
members at
#AHA23
presenting on:
- ECG/Wearable detection of structural heart disorders
- ML to accelerate RCTs
- ML-driven efficient risk factor testing
- NLP for assessing care quality
- Geospatial eval of care access
+more
Details:
Congrats,
@SpatzErica
- leader & role model for many of us
@YaleCardiology
@YaleMed
& nationally for a major
@PCORI
grant
Just amazing when phenomenal people are rewarded, especially for meaningful science you know they are incredibly passionate about.
In
@JACCJournals
today, we present our data experiments evaluating concerns whether US hospitals were delaying or deferring readmissions within the 30-day period to comply with the 30-day readmission metric.
w/
@hmkyale
, YF/ZQ,
@khurramn1
#JACC
Scientist: I will carefully plan my entire life around NIH grant deadlines/reviews to ensure team is covered, + resources to do science. Also, 😀 thatlab finally together after COVID
Government: oh too easy. Let us shutdown - no grant reviews/study section mtgs/NOAs - now plan
It is an incredible privilege to celebrate
@cards_lab
members achieving major career milestones.
We're celebrating Aline (
@af_pedroso
) successfully defending her PhD thesis
@ufsjbr
with lab members joining across continents.
Congratulations, Dr. Pedroso Camargos!
Strongly recommend
@guptaarjun90
’s
@NEJM
piece on the travails & superhuman-ness of caregivers.
A beautiful piece made possible by Arjun’s brilliance & thoughtfulness as a physician, & the ability to put emotions into words like few others.
@hopkinskimmel
Most of my Cardiology colleagues are triple to quintuple-boarded 😀
Not to be outdone, but not having the bandwidth to do another clinical board, glad to be able to "grandfather" into Clinical Informatics board certification!
#TripleBoarded
#kindof
@YaleBIDS
@YaleSPH
@YaleMed
Medical training teaches replacing fear with preparation.
As a medical trainee for all of my adult life, scheduled to be on inpatient cardiology consults in ~2 wks, in a city with early community spread, here’s my prep list
What’s on yours
#medtwitter
?
#coronavirus
#COVID
ー19
We discussed
#REVIVED
BCIS2
@YaleCardiology
fellows JC today (led by
@ekoikonomou
) - one thing that stands out is how are these patients recruited to OMT alone when CABG would have been strongly recommended in many?
No clear mention in the design/screen - this is all it says: