Kaitlyn Sadtler, PhD
@KSadtler
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Immunoengineer @NIBIBgov || @NewVoicesNASEM || BS, ScD hc @UMBC , PhD @HopkinsMedicine , PD @MIT (views≠NIH)
Bethesda, MD
Joined June 2015
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Pinned Tweet
Hear about how our immune system can help in tissue regeneration. My
@TEDTalks
from TED2018 in Vancouver is live on !
#immunology
#bioengineering
#regenerativemedicine
#WomeninSTEM
@TEDFellow
@MIT
@HopkinsMedicine
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Ok our lab manager just introduced me to this and HOW DID I NOT KNOW THIS EXISTED 🤯
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I’ve been told before I’d get a job and I got a job because I was female applying to engineering departments.
Not my PhD from Hopkins, my postdoc at MIT, my publication record. Because I was female. This was in 2018.
So yeah. Not shocked when I saw this gem of a tweet.
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Does your lab have a millennium falcon tube holder? Because ours certainly does.
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One of my other favorite things in our lab: bench organizer with parafilm spot.
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I don't know who needs to be aware of this or if I was just living in the dark but they make freezer racks for -80s that can store loose items. Want chaos? Here's your chaos drawer.
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For a moment I was very confused as to why a politician was wishing a cytokine good luck.
Thank you, IL-16. Good luck, Kevin. Kinzinger out ✌️
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Dear companies. Put the price range of a scientific instrument ON YOUR WEBSITE. It doesn't have to be exact. But it would be nice to know if I am dealing with something that is $10K or $50K
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Had to make sure we had enough ELISA plates to test all the samples. And it was the end of the fiscal year. Thus. ELISA Throne.
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Now that everyone is interested in immunology can we talk about how cool of a protein AIRE is?
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Two years ago I was approached to be in a children’s book about
#womeninSTEM
. It was officially released last week and I got my copy! 🤩 (forgive the tired face)
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I’m going to bed but as this thread is reaching a lot of folks remember to look for non-white women in these spaces as their experiences are compounded. Expectations to prove one’s self to show that you weren’t just hired to tick a box grow exponentially w/ intersectionality
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By July of 2020, 16.8 million people in the US had
#COVID19
-- and didn’t know it. Read our pre-print
@medrxivpreprint
🧵👇 (1/13)
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Why cant all FACS staining look like CD4 & CD8 in lymph nodes.
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I called a control group in a clinical study “WT” and this is why I’m not a clinician.
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Dear scientific journals. Can I just send this in as our cover letter 🤣
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Excited to announce I will be starting my lab as an Earl Stadtman Tenure-Track Investigator & Chief of the Section for
#ImmunoEngineering
at
@NIBIBgov
. Thanks to
@NIH
for investing in research in immunology & regenerative medicine! Ready for this new adventure.
#NewPI
#womeninSTEM
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Cross-presenting cells (cDC1s) play an important role in wound healing, and might be chatting with some non-conventional CD8 regulatory T cells. Check out our new
#biomaterials
#immunoengineering
paper on traumatic muscle injury in
@NatureMaterials
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I dont know who needs to hear it but Ctrl+Cmd+Space on a Mac brings up symbol/emoji addition to any text space. Ex: ± ɣ β μ ≥ ⌬
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*drumroll* Introducing the speakers for the FIRST biomedical engineering interest group seminar series at the
@NIH
@IRPatNIH
. Nanoparticles, bioreactors, macrofluidic systems, and hydrogels, oh my! Get ready NIH-ers
#bioengineering
#sciencetwitter
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Accepted ☺️ First senior author pub ✅ Got the keys to the lab in late January, and 8 months later we've got a publication!
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Do you ever read reviewer comments and just think, "who hurt you?"
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Guys. I know we all fell in love with eppendorf’s weird little 5ml Eppies. I introduce you to— the 25ml eppie! I couldn’t stop laughing when the sales rep handed me this.
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Just saw a goose honk and chase after a Postdoc. Spring has arrived at the NIH.
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I guess this means I am officially a PI! Are you a PhD student looking for a
#postdoc
or an undergrad looking for a
#postbac
? Want to do
#immunoengineering
&
#regenerativemed
research steps from where you can advocate for science funding? Come join the
#SadtlerLab
in DC!
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I will say this once I will say it again. I will hire someone that has passion and potential over great technical skills and apathy any day. Trust is a huge part of science and without the personal connection to drive it forward, it's easy to get lost. Passion & potential, 100%.
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A little less pomp and circumstance compared to other years with no ceremony, but I've been awarded the 2021
@HopkinsMedicine
Outstanding Recent Graduate Award. Thanks so much to
@CMM_JHU
and my thesis advisor Dr.
@JHElisseeff
for making Hopkins feel like home.
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I grew up jumping over hay bales for fun. Life takes some interesting turns.
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I am really, really tired of working as much as I do... On hard days and nights I remember advice from my PhD advisor, “truth takes the stairs”… though these are a LOT of stairs.
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We thought there were 3 million cases by summer. There were actually 20 million. (13/13)
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To the people that have followed me after posting about Parafilm. I'm going to eventually run out of useful lab items and you will be left with sarcasm and immunology.
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Being a PI.
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I was planning on not taking ibuprofen after vaccination just in case... glad to see my plan have some scientific backing as opposed to just "anti-inflammatory, thats the last thing I want!"
This work by
@WilenLab
@chennifer_jen
@StephanieEisen
shows non-steroidal anti-inflammatory drugs (NSAIDs) dampen antibody response to
#SARSCoV2
in mice. Important implications.
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Please consider the negative impacts of delaying tenure clocks and instead adjust expectations for ECRs given the circumstances. Signed, a female ECR thats really trying to get tenure & job security before having kids.
It should come as no surprise that the pandemic has caused significant stress/loss of productivity in academia.
@NIH
released some survey findings; note that the folks most affected are ECRs, women and URMs. So, what will NIH do about it?
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I just got an email from my old history teacher from
@FCPSMaryland
@UHS_FCPS
saying she was proud of me 🥺
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Exciting day today. Our standardization and validation data for our
#SARSCoV2
serology assays are online
@medrxivpreprint
! Huge collab between
@NIBIBgov
,
@FredNatLab
,
@NCATS_NIH_gov
, and
@NIAIDNews
. Also, personal news, first corresponding author paper!
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Post cool science from our lab: 0 new followers.
Post millennium falcon tube holder: 30 new followers (for me, thats a lot)
I don't understand this bird app and I never will but I'm glad y'all're as nerdy as I am.
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When you get editorial bounce-back because the conflict of interest statement needs to be before the references section.
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You gotta admit. Pandemic lab photos look like bad 90s album covers.
@NIBIBgov
Section on Immuno-Engineering. With:
@MKarkanitsa
@DrRavilokwani
@ParinazFathi
@adusei_m
@_tranngo
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It’s one thing when you’re in grad school and your PI asks how soon you’ll have the data. It’s another thing when you’re a PI and the Senate asks how soon you’ll have the data.
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NIH is working as a team intramurally to see who has PCR equipment willing to open it up for use in COVID testing. I signed up w my thermocycler & RT-PCR machine. Testing saves lives. So many scientists coming together for human health— this is why we’re here.
#fightthegoodfight
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Two for Two! Huge congrats to Tran Ngo (current postbac,
@_tranngo
) and Maria Karkanitsa (former biologist,
@MKarkanitsa
) on receiving the
@NSF
#GRFP
! Amazing scientists & future
#immunoengineer
leaders, very well deserved! I'm honored to have been able to work with them 🥰🚀
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Did I sit quietly and drink beer by myself in a pub at 3pm jet lagged? Yes. Did I also walk 5 miles in sandals with no arch support because I like wandering? Also yes.
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@soragnilab
@ArmaniLab
Let’s not forget: The year: 1881, the subject: squirrels. The conclusion: they swim sometimes.
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I have a paper that’s been cited almost 30 times and hasn’t been published yet (from last summer, it’s now accepted). As a
#newPI
I cannot express how ridiculously thankful I am for
@medrxivpreprint
&
@biorxivpreprint
servers. Gives new labs’ work a chance to be heard!
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To the people who have followed me here because I posted about a 96-well plate holder.
That’s about what you should expect from this account.
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FINALLY. The group's first officially proofed and published manuscript is available
@NatureComms
. This is expanding on our preprint that was posted early in the pandemic on optimizing ELISAs for
#SARSCoV2
detection.
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Female junior faculty during conference calls after getting cut off 10 times while trying to say something.
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I’ve been handed over my lab space, and the boxes have started arriving. Can’t wait to get a break from paperwork and start cool science!!
#immunoengineering
#newPI
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Apparently Gwenyth Paltrow said she went off the rails by eating bread, pasta, and drinking alcohol during the pandemic. Yeah. That's a Tuesday.
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First vacation as a tenure-tracker and leave is more stressful than being at work because I’m watching my to-do list exponentially increase after feeling like I’m already behind 😕 any suggestions on how to shake the guilt and actually disconnect?
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The largest burden of undiagnosed infections was in Black/African Americans (14.2%). Hispanic, younger (18-44 yrs), female, and those that lived in urban areas, all had undiagnosed seroprevalence estimates above the national average. (7/13)
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Congrats
@HopkinsMedNews
investigator Gregg Semenza on his receipt of the Nobel Prize in Physiology/Medicine! And yes, when you’re a scientist at the airport at 5am you live stream
@NobelPrize
. Congrats to all the scientists working on oxygen sensing who weren’t recognized today.
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I love being dragged in comments of news articles for saying “Good science takes time.”... you know what happens when you don’t do due diligence? Thalidomide. Thalidomide happens.
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Next week is my last week in the lab as a postdoc
@MIT
@kochinstitute
before starting my move down to DC to begin as Chief of the Section for ImmunoEngineering in
@NIBIBgov
. My
#postdoc
years have been challenging and rewarding. Looking forward to living in MD again! 🦀🌻
#newPI
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Since myself and one of our histology technicians share the early September birthday timing, both love cake, and coincidentally,
#MST3K
, I made her a cake. Or... should I say MST3-Cake. Please let this make it to campus unharmed 🤞.
@MST3K
@feliciaday
#moon13themoon
#idontbake
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Six years. The moment I signed the paper and got my PhD.
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2023 was a big year for us. After spending the first 2 yrs of our lab working on COVID, we pivoted back to regenerative medicine and published our first biomaterials immunology paper in
@NatureMaterials
.
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Lab photo number two! I’ve fully embraced that I’m the person that does the paperwork so they can do science and the Birkenstock’s are just a part of the daily wardrobe now. The
@NIBIBgov
Section on
#Immunoengineering
before our first fellows become our first alumni.
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Section on
#Immunoengineering
@NIBIBgov
photo 3! 90s band cover prevails. And I've added a new element to the PI outfit, the birkenstocks are now accompanied by a coffee mug.
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Just tagging in on the friendly reminder. I had 0 fellowships in grad school and no scholarships in undergrad. My first first-author paper was in Science. Fellowships/awards aren't necessary for doing good quality research.
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I will always celebrate this day. 7 years ago today, I became the first person in my family with a PhD.
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Submitted my first corresponding author paper for publication. Lets take bets on how long till it gets triaged 😂😭
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Have you ever seen anything so full of splendor?
This 5 laser spectral flow cytometer arrived in my lab this week and is up and running! 😍
#immunology
#immunoengineering
#newPI
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#Immunoengineers
and
@ForbesUnder30
alum at the
@SFBiomaterials
conference! Great to see
@DrErikaMoore
in person, finally!
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Me: "How are you doing?"
Friend: "Excellent"
.... "wait seriously?"
"No I want to quit"
Thaats more like it. Reminder that COVID research scientists are very burnt out. Constant "we need this data now" and pressure to be perfect, fast.
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That’s my face!
To help us get a better understanding of how much
#COVID19
has spread undetected in the U.S., researchers from
@ncats_nih_gov
,
@NIAIDNews
,
@NIBIBgov
&
@theNCI
came together to create the
#NIH
Serosurvey Study. Hear from some of them on their roles:
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Today is my 5-year PhD-iversary. I will never stop celebrating this. A cumulation of 3.5 crazy years, wrote my dissertation in 3 weeks & scheduled my defense after my paper got accepted in Science, so I could make the deadline for the spring hooding ceremony.
#womeninSTEM
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All immunologists I know have been saying this. Local delivery to the site of infection will help with tissue-specific immune responses. In this case, a chance for more dimeric IgA.
Of the ~100
#SARSCoV2
vaccines currently in clinical trials, only seven are delivered intranasally—despite this type’s long success against influenza. A new
#SciencePerspective
argues that intranasal vaccines could be beneficial against
#COVID19
.
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Dear future lab members. If I get tenure I will be making myself this cake.
No publication data was leaked in the making of this cake.
#flowcytometry
#cake
#sciencetwitter
#AcademicTwitter
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@EricTopol
@CNN
@maggiemfox
@CDCgov
That’s why we spent enough time at the
@NIH
to get things right, check out our preprint! Our statisticians showed you need at least 300-1000 archival negative controls even with 100% specificity for good CI’s
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"This manuscript is an excellent addition to the scientific literature that represents a major advancement in the field of regenerative medicine." 😭 y'all today is a good paper day.
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Most working on serology are hesitant for "immunity passports" as antibodies alone don't = immune. Neutralization assays on virus itself, challenge studies are gold standard. This is why
#basicscience
research is important & to think past primary endpoints of serosurveys.
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If anyone sees me staring off into space and whispering to myself for several minutes this week. I’m ok. Practicing my
#TEDtalk
. T-minus 6 days till Vancouver and 9 days till the fellows take the stage! Super excited.
#WomenInSTEM
@TEDTalks
@TEDFellow
.
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There were >3000
@NIH
Director's Awards. Though I'm proud of the team's serosurvey award (52 recipients across 4 ICs), this one I'm most proud of. There were only 10 mentoring awards: for folks in CC, NCI, NHGRI, NIA, NIBIB, NICHD, NIDCR, NIGMS, NIMH, NIMHD.
#mentorship
#newPI
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The boss's boss's boss's boss (?) tweeted about our study! Woohoo! Also, I'm investing in an ELISA robot. We might need more than one.
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Y'all got the explainer previously on our preprint, out in
@ScienceTM
, our multi-
@NIH
IC collab with 3 female co-first authors. 👩🔬👩💻🚀💫
@ncats_nih_gov
@NIBIBgov
@NIAIDNews
@FredNatLab
@PittTweet
@UABNews
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Congrats to
@KWhiteheadLab
for her fabulous
@TEDTalks
on lipid nanoparticles for mRNA therapeutics. Along with a standing O at the end!!
#immunoengineering
#womeninSTEM
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We were asked & delivered --
@MattWolf_PhD
and I teamed up with our
#immunoengineering
groups to write a brief guide on things to consider for spectral flow cytometry on highly autofluorescent samples -- I'm looking at you
#biomaterials
.
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I dont know who needs to hear this but any large matrix-style dataset you've got that is a csv with simple column headings can be opened into a workspace in FlowJo, it auto-generates an fcs file from it, and you can play with it like FACS data (gating, etc).
#datavisualization
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Realizing you’ve got a press call in 10 min, haven’t slept, no makeup and are wearing a T-shirt with a shark on it that says “hangry”.... cover it up with a lab coat. Improvise. Adapt. Where’s my coffee.
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I’m seeing stuff about a COVID preprint I’m not going to retweet. Let me make it clear: we can make cats glow under the right lab conditions. Doesn’t meant they’ll just randomly have GFP incorporate into their genome in real life.
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Huge congrats to the incomparable
@mhhettiaratchi
for her Young Investigator award at
#TERMIS2024
world congress! 💪💪
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HUGE CONGRATS to
@NIBIBgov
postbac (future Dr) Kenneth Adusei on you
@NSFGRFP
!!! It’s been amazing to have you in the lab and I can’t wait to see your future in
#immunoengineering
research... Again... Please remember me when you’re famous.
#proudPI
Found out today I received the
#NSFGRFP
. It has honestly felt surreal. From the bottom of my heart I want to thank God 🙏🏾🙏🏾🙏🏾 and everyone that has invested in me because I know that I’m here not by my own doing but because of the mentorship and guidance of so many ppl.
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Position opening in my lab starting summer2024 - postbac IRTA, 2yr position, salary+benefits (health insurance, free parking/metro), Bethesda MD, muscle trauma + immunoengineering. Contact me if interested, immuno experience preferred not required
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