RT @IUGastro: For #ManuscriptMonday, @rajVuppaLanchi's study shows Saroglitazar Magnesium is safe in cholestatic cirrhosis. #LiverTwitter…

Intranasal zavegepant (10 mg) has no clinically relevant QT prolongation, supporting its cardiovascular safety and the use of concentration-QTc analysis in place of dedicated TQT studies. #PSPjournal #ASCPTjournals #ClinicalPharmacology

This study demonstrates how PK modeling can guide the early design of subcutaneous controlled release systems for biologics, optimizing dosing regimens and enhancing treatment efficacy. #PSPjournal #ASCPTjournals #ClinicalPharmacology

New systematic review evaluates covariate modeling methods in population pharmacokinetics, from SCM to AI. Could alternative methods outperform SCM in predictivity and efficiency? Read more: #PSPjournal #ASCPTjournals

A study describes how ervogastat w/wo clesacostat reduces liver fat in NASH using PK/PD modeling, paving the way for integrating biopsy data in future studies. #PSPjournal #ASCPTjournals #ClinicalPharmacology

Global collaboration in #RealWorldEvidence: Beck et al. share insights from the ICMRA COVID-19 RWE Working Group, highlighting lessons, successes, and recommendations for future health emergencies. To learn more: @ASCPT_ClinPharm #CPTJournal

Check out our latest #translationalbytes on 'Why do Diabetic Participants Enroll in Clinical Trials?" to learn more about patient engagement for clinical trials. #CTS #ASCPTJournalFamily #clinicaltrials

Ringing in 2025 and looking back on a strong 2024. Check out our latest #translationalbytes on a successful 2024! #CTS #ASCPTJournalfamily

Building confidence in #PBPK modeling of CYP3A induction: Reddy et al. evaluate rifampin DDI predictions across CYP3A substrates, highlighting challenges and key insights for model refinement. To learn more: @ASCPT_ClinPharm #CPTJournal

🚨 New Perspective Alert! Dive into "First, Do No Harm: Addressing AI's Challenges With Out-of-Distribution Data in Medicine," exploring how OOD detection can make AI in healthcare safer, more reliable, and trustworthy. 📖 Read now: #AI #HealthcareAI

Enhancing #Pharmacogenomics in EHR: Grant et al. surveyed 305 clinicians and found simplified, patient-specific alerts reduced stress and improved decision-making compared to generic warnings. To learn more: @ASCPT_ClinPharm #CPTJournal

Wang et al. developed a longitudinal exposure–response model using ordinal regression to describe ritlecitinib efficacy in alopecia areata patients for the Eyebrow and Eyelash Assessment scores: #PSPjournal #ASCPTjournals #ClinicalPharmacology

RT @NIMMLab: Our paper on Positive First-in-Human Data of NIM-1324, a Phase 2 Candidate for Systemic Lupus Erythematosus, was accepted to t…

Curious about causal inference in pharmacometrics? This tutorial introduces potential outcomes, g-formula & DAGs—key concepts bridging PMX with AI, biostats & epi. #PSPjournal #ClinicalPharmacology

Can #RealWorldEvidence support regulatory approval? Nisha Sharma et al. delve into the off-label use of mycophenolate for lupus nephritis and other conditions. Discover its potential to influence regulatory pathways: @ASCPT_ClinPharm #CPTJournal

Check out the special themed issue: "Therapeutic Innovations in Rare and Orphan Diseases" now available online from #CPTjournal:

Get to know Regulatory Science (RS) Vice Chair Andrew Riselli in this month's #CPTjournal #IamASCPT:

The deadline to save on your #ASCPT2025 registration is getting closer! Register today:

You've read the #TranslationalBytes post - now check out the article from #CTSjournal!

Learn about current applications and challenges to integrating AI/ML in Clinical Pharmacology workflows at this upcoming #ASCPTwebinar (1/31 at 1:30 pm ET)