If this is the rationale put forth by what is now the leading health and wellness influencer in the world, we have no chance. This rationale that “I don’t go where the flu is” is impossibly dumb and detracts from the systematic efficacy of flu vaccines in a community/population
Andrew Huberman just released an episode on "How to Prevent and Treat Colds and Flu."
Flu shots? Only decreasing chances of catching flu by 40-60%, and only if the strain is targeted correctly. Huberman doesn't get the flu shot, and implies you probably shouldn't either.
@SimmonsBart
@joerogan
Because the CDC and NIH have a threshold for data quality and, frankly, existence. Frivolous claims for 21st century notoriety don’t rank very high on the evidence hierarchy.
I am a phd candidate who does a sizable fraction of my research in neuroendocrinology and the HPA Axis.
Adrenal fatigue is not a real thing. No. This is full on quackery.
Adrenal insufficiency or Adrenal fatigue commonly sabotages your weight-loss efforts.
Common warning signs to look out for include
Changes in mood
Fatigue
Gut disorders
Irregular menstrual cycles
Low sex drive
Weight gain
Water retention
Skin problems
Dizziness
#adrenals
#keto
You would have to eat nearly 4.5 pounds of raw almonds in a narrow window of time to even approach toxic doses, assuming 100% conversion and no further metabolism of hydrocyanic acid to cyanide (which…no).
Stop with this.
@nacholeber
Same as any president in any other lame duck session, punctuated by what is by most objective metrics one of the 2 or 3 most productive terms in the last 50 years.
Erythritol paper getting lots of legs, which is too bad because there are many better papers in NM everyday.
Linked is a great thread for a synopsis of key takeaways, but I am still seeing people and media make spurious claims, so let's look at the relevant biochem/metabolism 🧵
I will tell you to do 2 days with zone 2 cardio, 1 day with high intensity work, and to lift 2-3 days per week hitting 6 major movement patterns for $15/yr, and I will immediately turn around and donate it our local homeless services and humane society (50/50 split)
This is Peter Attia.
He's the
#1
longevity doctor in the world & hiring him costs patients $150,000 per year.
His message? Exercise is the only longevity drug you'll ever need.
His 10-step routine to living a longer and healthier life:
My two big nutritional gambits in life:
1. The benefits of protein on body comp, satiety, and lean mass preservation outweigh the downsides for aging in humans
2. Artificial sweeteners pose no/minimal harm to humans.
We talk about causes of obesity and such quite often, yet I think the most underrated part of the discussion is the role alcohol and all that goes with it plays in the equation. If people stopped drinking and cut out the calories that went with it,we’d be a long way down the road
I will bet you as much money as you want that if a group were randomized to eat 15 chips per day or smoke 15 cigarettes per day, the chips group would turn out better on any ascvd metric you chose (or mortality).
I would literally bet the house.
The comments to a new UK Daily Mail article warning about vegetable oils reflect mass frustration among health-conscious food consumers.
You'll see jaded remarks like “health experts are just trying to sell books” and platitudes like “everything in moderation.”
Let me tell you
There is no evidence that caffeine ingestion in the morning is detrimental in any way, and any modest further increases in sympathetic or neuroendocrine output has no demonstrable effect on health.
If you want coffee first thing, have it
1. Avoid coffee for the first 90 minutes after waking.
We have a natural cortisol spike when we wake up.
Adding coffee to this can increase your stress response and blunt the impact of the caffeine, making you immune to it in the long run.
Drink coffee after this spike.
The evidence that heat stress positively influences accumulation or preservation of skeletal muscle is about the same as the evidence that I’m a good NBA prospect.
The most important players for muscle mass:
1) Protein intake (at least 1.6g/kg body weight)
2) Resistance training
3) Omega-3s (2-4g/day, triglyceride form)
4) Heat stress (from a sauna or hot tub)
The sudden denigration of BMI is odd.
It’s an imperfect metric, namely when looking at an individual. But it also is fairly representative at the population level. Adding waist circumference (which can also just be used it in isolation) makes it quite representative of…
BMI Won’t Die by
@yeahyeahyasmin
"BMI has become like the decrepit car you keep driving because it still sort of works and is too much of a hassle to replace."
#healthylifestyle
1. Soy protein absorption is perfectly sufficient.
2. No evidence of endpoint differences as a result of phytoestrogen consumption at typically intake levels.
Soy is NOT a good substitute for meat.
Even organic (non-GE) soy contains
-enzyme inhibitors that interfere with protein assimilation and therefore lower its bioavailability
-high levels of phytoestrogens, which are endocrine disruptors
-extremely high levels of phytic acid
It’s not carbs. It’s not fats. Most evidence suggests it’s not even increases in sedentary behavior (although I’m not ready to dismiss a small role).
It’s access to calorie dense, highly palatable foods with little to no friction. Is the common denominator everywhere.
1/2 China probably has the highest increase in obesity and T2 diabetes in the world…Are we sure it is because of carbohydrates? 🤔…or maybe Sedentarism is the primary cause?…
The remarkable shift from high CHO/low fat diets where overweight rates were among the lowest in the
I literally eat peanuts by the pound and I currently have a BF% of about 9%, and A1c of 4.8-4.9, inflammatory markers below detectable limits, and a lipid panel that id put against anyone.
Peanuts are fine. You can comfortably avoid just about anything this gentleman says.
“Resetting” the dopamine system is not a thing. Not only would describing the entirety of dopamine signaling encompass an entire textbook and then some— the concept of resetting anything is worthless nebulous, let alone to put some ultra-specific time course to things.
I used to think something similar.
Then I saw how much sunscreen you’d have to apply to reach levels with any demonstrated carcinogenic properties, and now I don’t worry as much.
I’d encourage Dr. Patrick to supply her audience with the same.
Let's talk sunscreen
"It really, I think, is pretty clear that avoiding the chemical sunscreens, for now, seem to be the way to go, and using the mineral-based ones are a lot safer." -
@foundmyfitness
Notably, two chemicals to watch out for:
• Octisalate
• Avobenzone
They
I’m going to say something controversial:
90% of healthy aging is staying as close to a healthy (often lower than one might think) weight, recommended exercise volume, basic economic security, and sufficient sleep.
If genetically or environmentally at risk,
I went to a longevity clinic to get a 360 overview of my health
- 180 blood markers
- DEXA scan
- VO2 max test
- resting metabolic rate test
- full body MRI
- echocardiogram
- physiotherapy
- sleep apnea test
Full video:
No one:
Internet gurus:
Things I leaned without a $50k/yr degree:
Vaccine denialism
Nutritional zealotry
Anecdotes>peer-reviewed data
I’m entitled to my own facts
Cherry-picking—>👍👍
Keto/carn/vegan/paleo/gluten🚫=panacea
Calories don’t matter
Academics are brainwashed morons
This really makes me wonder if Attia (his team? His consultants? Idk) have even the slightest handle on nutrition science.
This is like a sophomore undergrad research class level critique that misses just about all of the subtleties of doing translatable nutrition research.
So unfortunately this represents a pretty severe lack of understanding of cancer metabolism and cancer cachexia-- a phenomenon that seems to uniquely be directed at those battling cancer.
Let's talk about cachexia and why having a Coke is fine for individuals with cancer... 1/n
I was told today about a doctor who recommended a cancer patient drink Coca-Cola. This was to help avoid wasting away known as cachexia which can occur is severe chronic illness. Unfortunately cachexia is wasting of muscle tissue, while Coke only makes you fat.
#DoctorFail
Tomorrow is the last day for this guy. Got him a month into the ol’ MD/PhD run, and he’s arguably been the most consistent part of life since. I don’t know what i will do without a tail wag and a big smile to greet me at the door, even when I interrupted a nap.
All the love, Shi
He’s a science grifter who preys upon lack of science communication and male role models to disseminate a college sophomore neuro major level set of extrapolations and shoddy corresponding recommendations. He got hit with a hit piece here that had maybe the best receipts
This is what happens when you get super popular, even if you avoid politics. The media will try and massacre you.
Andrew Hubermann is fantastic. He’s super smart and has helped millions of people lead healthier, happier lives.
Yet the media doesn’t see that. They see a rich,
Wearing a seatbelt:
You can still get pulled over.
You can still break your arm in a crash.
You can still be hospitalized for injuries following a crash.
You can still die in a crash.
What’s the point?
The Pfizer mRNA vaccine:
▪️You can still get covid.
▪️You can still spread covid.
▪️You can still be hospitalized.
▪️You can still die of covid.
▪️You can get side effects.
So what's the point?
The number of people who bash glucose because “the body can make all the glucose it needs,” but then turn around and defend saturated fat— a molecule the body can make as much of as it needs—is simply baffling.
@hubermanlab
@RyanMarino
Does it not strike you as concerning the relative frequency in which you are having to acknowledge and address blatant falsehoods in your content at this point? Is that the right framework for a science communicator? Move fast and break things?
Agree. It's disgraceful that
@BCCHF
and
@cpsbc_ca
allow him to keep harassing other physicians online. My school aged children know that online bullying is an atrocity, yet this pediatrician does this everyday? Horrible.
This is frankly great advice, and the fact that the low carb and anti-pharma people who are suggesting that this is some nefarious handshake between the ADA and Novo Nordisk (or insert corporate boogy man of choice) are out of control.
Curious about meal planning with diabetes or prediabetes? Listen as Stacey, the ADA's Director of Nutrition & Wellness, reveals the secret to starting simple: the Diabetes Plate Method. Learn more this
#NationalNutritionMonth
at . 🍽️🥦🍎
@eatright
Attia’s choice to position himself in a weird anti-incretin drug space is so odd, especially after it’s efficacy data in trials is so much higher than some of his favorite drugs.
Idk if it’s a threat to his whole story, a sunk-cost thing, or just inaccuracy, but it’s a mess
1/
@PeterAttiaMD
suggests semaglutide makes his patients “fatter” due to his patients losing more lean body mass relative to fat mass (LBM:FM). He claims the data was generated by an in-house pre-post DEXA case series (unpublished). Let’s evaluate that claim…
If we are now at the point where people that teach med students are arguing that deep frying is just nothing to think about if it uses a high-percentage sat fat fry oil, we are doomed.
Potatoes are likely the closest thing to a single food that could sustain humans in reasonable to good health. So, uh, this would appear to be a false statement.
I could unpack this 7 ways to Sunday, but I’ll leave it at this:
In sports, it is quite rare to see an outstanding player (elite professional) become a best in class coach. It is much more common to see guys who barely spent time on a roster or came up through the film room.
I think it’s fair to ask if the MD or scientist or public health official saying to do X or not do Y looks and sounds healthy and vital. I avoid going to a dentist with bad teeth. What do you think? I sense diverging opinions on this.
It’s hard to exaggerate how bad this logic is.
Treatments with high efficacy have no obligation to be the core driver of the development of the pathology. See melanoma and checkpoint inhibitors as perhaps the best example.
There aren’t enough facepalm emojis for this rationale
Obesity is not an Ozempic deficiency.
Heart disease is not a statin deficiency.
Diabetes is not a metformin deficiency.
Depression is not an SSRI deficiency.
ADHD is not an Adderall deficiency.
We’re being lied to.
Hey,
@KenDBerryMD
, I looked.
Here is a head to head comparison of 100g of wild strawberries versus 100g of conventional strawberries. It’s 4 grams of sugar versus 5 grams of sugar. That’s 1.25x, not 100x. Just a bit different. Maybe more science next time.
It’s health fair day here, so time for updated numbers:
BP: 116/54
Total cholesterol: 143
HDL: 80
LDL (calc): 54
Trigs: 49
Glucose: 86
A1c: 4.8
A significant increase in carbs has failed to kill me, it would seem.
I was dumb enough to listen to this.
At multiple points, they get the basic biology wrong (or at least woefully incomplete).
It’s impossible to advance this discussion if basic biological/neurobiological rigor is not a prerequisite.
One of the best conversations I've hosted on
@thehonestlypod
and by far the most heated.
Is obesity a matter of willpower or genetics?
And is Ozempic is a silver bullet or an expensive Band Aid?
Grateful to
@Chikagirl
,
@VPrasadMDMPH
,
@calleymeans
:
The new definition of madness, you now inject yourself daily, for life with expensive drugs to lose weight. So now you can daily eat crap food, still get sick but not fat. Fake food companies win, big pharma win, but you die young but slender. Pls stop this madness.
Had I known I could just write books about my vaguely aligned musings on various buzzworthy topics in the health-o-sphere, I could have saved myself a lot of working hours.
I’m excited to share some big news.
I've been working on a book for quite some time — more than five years, in fact — though it's really based on more than three decades of research and experience. Today, I am thrilled to share that my new and first-ever book, Protocols: An
A reminder that Mr. Rogan here co-runs a supplement company that sells rather expensive supplements (well above market prices), often extolling the efficacy of their most popular product based on this trial
That would be a great suggestion if you could assure that the industry you were representing wasn’t completely captured by heartless monsters who have a history of some of the biggest criminal fines in human history because their deception has cost hundreds of thousands of people
This is the dumbest thing you’ve ever said, and you’ve said more than your share of incredibly dumb things.
Go to the data and actually look instead over parroting cliche disease-denialist tropes
As is you had any credibility Left, claiming a “casedemic” cleared the rest of it
Prediction: lockdowns are coming back in the US due to horribly incorrect interpretations of the viral data. This is a case-demic, not a pandemic.
Metabolic health also remains the major arbiter of the severity of the disease, yet the media will never discuss this.
First of all, this is a sad state of affairs.
Second, I don’t know what is up with exactly this tweet structure popping up everywhere, but people riding the wake of pseudosci influencers is a terrible trend.
The most popular scientist of our time?
Dr. Andrew Huberman.
I’ve listened to his fat loss podcast 3 times.
Here are his top 5 science-backed strategies to help you easily & effectively shed body fat:
Editors note: this is false.
In fact, aggregate data suggests that individuals who consume more plant oils as an isolated variable (I.e not as a proxy for deep fried or packaged food consumption) are healthier, have lower cvd markers and risk, and do not suffer from “toxicity”
Today there is more evidence that seed oils are toxic than there was for cigarette toxicity in the 1970s when the surgeon general first started warning the public about smoking.
Yet health authorities tell us seed oils are heart-healthy.
Where is the disconnect?
I am honored
I was wrong. This is the dumbest thing I’ve ever seen.
And I’m on papers on the topic.
This guy is a scourge on intelligent thought. Anyone who takes this material as gospel should take time to take a hard look inward.
I hate to be a broken record, but while (again) I’m fine with people wanting to supplement omega 3s, most endpoints that have targeted supplemental omega 3s in humans has been underwhelming.
Disease states deplete omega3 index values, so risk of reverse causality is very high.
People with an 8% or higher omega-3 index have a 5 year increased life expectancy compared to people with a 4% or lower omega-3 index.
Supplementation with omega-3 can effectively increase someone's omega-3 index from 4% to 8%. However, the specific dose required to achieve
@nacholeber
The problem is that the waiver does nothing to address the actual problem. Several thousand person gatherings in air-circulating facilities is a fever dream for a contagious virus. It’s not about spreading to the people who go— it’s about spreading to people who chose not to go
Notably, if your preferred social influencer doesn’t have a great grasp of the differences between plasma lipoproteins and molecular cholesterol, it might be time for a new social influencer
Using our EBO2 machine, we filtered 7 litres of blood from a highly inflamed patient full of toxins.
This leftover residual is a mixture of heavy metals, petroleum by-products, inorganic substances, cellular waste, fat microparticles, and diseased, dead cells.
This frustrates me to no end. I don’t consider Fetterman to be a clown. He’s at least a serious person.
If he cannot grasp the massive leap forward scalable lab-grown animal protein represents, I really just don’t know what we’re doing anymore.
Pains me deeply to agree with Crash-and-Burn Ron, but I co-sign this.
As a member of
@SenateAgDems
and as some dude who would never serve that slop to my kids, I stand with our American ranchers and farmers. 🇺🇸
Bet Result Alert: Elite Horse Mind
@MarkDParrish
wins $450 as his horse, Medina Spirit, wins the 127th Kentucky Derby.
Mandaloun gets second, so no one cashes for that.
NEVER BET AGAINST PARRISH.
Raw milk ice cream is NATURES OZEMPIC (even better than ozempic 🤫)
Authentic ice cream is:
• Raw Milk
• Raw Eggs
• Raw Cream
• Raw Honey/Sugar
Why does ice cream get a bad rap?
Because commercial ice creams contain:
• Gums, dyes, artificial flavors, emulsifiers,
This is a disaster. The study linked to support the notion of dopamine level changes in the brain used 2.5 hrs of cold exposure in rats, which is the equivalent of 12+ hrs of exposure in humans. It also assessed dopamine “synthesis” in the stratum, where it is not synthesized
@StevenQuartz
@hubermanlab
Hi Steven, thank you for your comment.
I'm in agreement that the study we discuss in this clip measured plasma dopamine and therefore, we can't infer that this same effect (or its magnitude) would be observed in the brain, as peripheral dopamine doesn't cross the blood-brain
This man changed the game:
Dr. Peter Attia.
He dedicated his life to figuring out how humans can increase their lifespan & live to 100+.
Here are 5 game-changing habits he discovered (that you can start right now):
Hey
@Google
, your roping in of
@Examinecom
with the other websites who you have bumped down is a terrible flaw in your algorithm updates. Examine is at the cutting-edge or evidenced-based analysis, &
@sol_orwell
has always had consumer interest as a primary priority. Please fix
So many questions about seed oils, so here goes:
Folks like
@BioLayne
have argued (quite compellingly) that it’s calorie-density not seed oils per se that is problematic but there remains a very vocal “seed oils are a/the culprit” crowd. Here is what I know for certain: there
Dear people,
I know it’s not cool to do anymore, it for the next couple of months, can we all agree to listen to experts for a change. If you (royal you, myself included) don’t know what you are talking about, just say so. It’s fine.
Thanks.
No one argues that obesity is as simple as counting calories these days. This is a straw man.
What the argument actually is, is that caloric balance is the inescapable underwriting principle that determines weight balance. Many strategies are in service of that target.
It's unfortunate that some people still believe that obesity is as simple as counting calories.
As a psychiatrist, I welcome these simplistic thinkers to take the "psychiatric medication challenge."
These meds can make disciplined, calorie-counting people fat.
If you are not metabolically healthy enough to handle 9 grams of carbs but can handle 550+ mg caffeine and the associated glucose excursion, perhaps reconsider your priors.
An 8 oz cup of black coffee contains from 0.5-2 grams of carbohydrates. If you drink 3 12 oz coffees each morning then that's up to 9 grams of carbs...
For some people this is going to elevate blood glucose levels too much.
From sequencing the genome in January to shots in arms in less than a year. Huge debt of gratitude to all the scientists and healthcare workers that made this possible.
Also, the Bill Gates chip really improves the WiFi signal strength.
Tomorrow, I’m sitting down with
@BioLayne
to discuss all things nutrition and fitness for the Huberman Lab podcast. What would you like me to ask him? As you know, with Layne you’ll always get the straight, science-supported answer.
Dear Twitter people,
LC/Keto is a great tool.
Can we please stop painting whole plants (especially vegetables and berries) as things that are bad for health. It’s stupid, based on next to no science, and counterproductive.
Happy Sunday.
I’m a bit concerned about the seemingly increasingly popular trend of viewing nutrition through acute changes in blood glucose rather than things like chronic glucose and lipid values (the latter of which is pretty well captured by A1c)
This is such a willfully poor attempt at critiquing SELECT that is makes me wonder if he A) has shorted Novo’s stock at some point B) just doesn’t especially appreciate trial design C) does appreciate the totality of evidence, or the ability to correct for a variable (weight)
A new trial has reported that the GLP-1 receptor agonist semaglutide reduces risk of cardiovascular events in patients with obesity – but that’s not the question we ought to be asking.
Being criticized for not doing enough PubMed-based research and extolling my lack of understanding of the microbiome when I have published work on the microbiome on PubMed.
This is peak Twitter. Just can’t make it up.
@ZKForTre
@gerdosi
@trpdo
@ADreyzen
spend a few years doing research.
I met Gabor online...never met him in person.
He understand the microbiome better than the majority of physicians in practice.
the world is changing.
i am driving part of the change: Diabet(es)™
I can’t believe we live in a world where prominently platformed health influencers understand neither public health objectives nor the difference between recommending a limit versus a minimum amount.
I can’t believe we live in a world where the American Heart Association says it’s totally ok for a 2 year old to have 6 teaspoons of added sugar DAILY. This is NOT talking about natural fruit sugar (which is not considered “added sugar.” This is industrially manufactured ADDED
I am going to admit my naïveté for a moment here:
Handgrip strength correlates with mortality, too, but training grip strength does not increase longevity because the observation is reverse causality.
How strong is the actual evidence base that actively increasing VO2 max…
If you're looking to improve your VO2 max
Try the Norwegian 4x4
Probably the best workout there is for it
4 minutes hard (~75-85% max heart rate ... not all-out, but these intervals should be quite brutal)
Then 3 minutes lower intensity (similar to zone 1)
Repeat 4x
Here’s a hot take that i no longer think Is that hot in light of recent evidence, including the new Hall et al met ward study:
Mechanical satiety signals >= hormonal/digestive satiety signals.
Food volume matters. Big time.
Oh for the love of god 🤦♂️.
If had even taken the time, you would have noted the paper was about associations between food additives and CVD. Food additives that are most commonly added to… highly processed food.
At what point does this become embarrassing.
Increased intake of insoluble fiber cellulose is associated with worsening cardiovascular disease
FIBER
IS
ASSOCIATED
WITH
CARDIOVASCULAR DISEASE
💣💥
🃏All of nutrition science is a bunch lies built on a house of cards
Onnit, the company he co-founded that’s sells overpriced supplements with minimal efficacy, just was bought by fucking *Unilever* for $700 million.
There exists not shame in the world.
That would be a great suggestion if you could assure that the industry you were representing wasn’t completely captured by heartless monsters who have a history of some of the biggest criminal fines in human history because their deception has cost hundreds of thousands of people
@Damianrajkowski
@houghtbr
@Chris_Hawkey
Yes it absolutely does. You can look in my bio for my credentials.
I caution you against claiming things which are factually untrue and outside of your ability to assess
_
@RobertLustigMD
explains how the Food Industry adds fructose to a great many foods, making them addictive by virtue of the similar effects of fructose to drugs such as cocaine, heroin, amphetamines, etc. on the brain. (Excerpt from Huberman Lab podcast )
Alright, starting a seven day fast on Dec 30.
Not because I blew it over the holidays or anything— I was my usual mildly neurotic self and ate exactly zero junk.
Mostly just to get a sense for what i am doing to my mice when I fast them for 12 hours.
Ventilators Were a Death Sentence COVID Patients: This Was Known Early On, and They Kept Going Anyway
@ElonMusk
told
@JoeRogan
, "This [ventilators] is actually what is damaging the lungs, not COVID. It's the treatment. The cure is worse than the disease."
Dr. Mercola calls this