“That is one of the most important presentations we will hear.”—BCRF researcher Dr. Eric Winer on today's
#SABCS22
presentation by
@YAbdouMD
on BCRF-supported
@SWOG
RxPONDER data showing Black women have worse outcomes comp. to white women despite similar gene recurrence scores.
Excited and honored to present our newest race and ethnicity analysis from RxPONDER looking at recurrence score gene axes scores.
Join us May 31st at the Rapid Oral session, details 👇🏼
#bcsm
#ASCO24
@KalinskyKevin
Adding Pembro to SG did not improve PFS in unselected patients with HR+ MBC
Reporting negative findings is as important as reporting positive findings‼️
#ASCO24
@OncBrothers
@OncoAlert
#bcsm
It is with a heavy heart that I share the news of the passing of an incredible human being- Dr. Shekinah Elmore. I am deeply fortunate to have known her. Her kindness, dedication, and unwavering spirit left a lasting impact on everyone she met. This is a profound loss for the
Words cannot describe how profoundly sad I am to share the news of Dr. Shekinah Elmore's death this week.
Shekinah was a SPECTACULAR human with profound wisdom, an incredible generosity of spirit, & a heart of kindness that lifted us all up.
Taking a moment to acknowledge that many places, especially in third world countries, lack access to essential drugs and resources. We are fortunate to have more in the US.
A shout out to Dr. O’Sullivan for acknowledging that treatment paradigms are not applicable everywhere, we
Peer Review and Becoming a Successful Author -- a wonderful presentation and discussion that is sure to become a staple in the
#TECLounge
. Thank you to our presenters
@YAbdouMD
,
@PamelaKunzMD
, Dr. Robert Maki, and
@NazliDizman
.
A-Brave trial: adjuvant avelumab vs placebo in high risk TNBC
No significant improvement in DFS although statistical improvement in DDFS and OS were seen.
In high risk patients, I still offer adjuvant ICI if patients have not received neoadjuvantly, this data doesn’t suggest
Important work presented by
@TarahBallinger
looking at treatment-induced peripheral neuropathy (TIPN)
in Black patients.
Every 3 weeks docetaxel was associated with less grade 2/3 and less dose reductions due to TIPN
This highlights the importance of studying treatments in a
postMONARCH: First phase 3 trial to show benefit of continued CDK4/6i with abemaciclib + fulvestrant post progression on CDK4/6i
All patients benefited although efficacy more pronounced in:
➡️>12 months prior cdk4/6i duration
➡️no visceral mets
Spectacular presentation by
Thank you for the shout out
@Dr_AmerZeidan
!!!
The hacker
@PgambarRaj
took over my account and remains active despite being reported by many verified X users.
@X
does not seem to take impersonation seriously
#disappointed
A hacker took over
@YAbdouMD
original account including her followers & for reasons unclear to me that
@X
didn’t do anything about it. In any case Dr Abdou started a new account
@YAbdouMD
& she is the best so plz consider following her account
@acweyand
@AaronGoodman33
DB06: phase3 of T-DXd vs TPC in chemo naive HR+/HER2 low and HER2-ultralow
➡️ improved PFS 🔼5.1m (13.2 vs 8.1, HR 0.62)
➡️consistent PFS improvement in ultralow subgroup 🔼4.9m
➡️OS still immature
➡️ILD in 11% of patients and remains an important safety risk
👏🏼 ~85% of HR+
Largest study evaluating ctDNA in early, high risk HR+ BC showing patients who remained persistently positive or became positive on treatment with abema were more likely to experience an IDFS event compared to patients with persistently negative ctDNA or if ctDNA became
@MPishvaian
@prarthnavb
@TumorBoardTues
yes but we know from the right choice trial that even in symptomatic visceral crisis, first-line ribociclib plus ET showed a significant PFS benefit and similar response rates, over combination CT in these patients
INAVO120: Inavolisib with palbo and fulvestrant in PIK3CA-Mutant HR+ MBC
✅improved PFS (15m vs 7.3m, HR 0.43 )
✅ Delayed need for subsequent therapy (🔼8.9m)
✅Longer median time to deterioration in pain severity (🔼12.8m)
➡️ More drug = more toxicities although maintained
@prarthnavb
@TumorBoardTues
@MPishvaian
@JohnEbbenMDPhD
@BCJoyceO
There are no current randomized data comparing these 3 cdk4/6i, although an ongoing trial, HARMONIA (NCT05207709), will randomize first-line patients with metastatic HR + HER2-enriched breast cancer to receive endocrine therapy with either palbociclib or ribociclib. This trial