Nature Communications - Aziridines are useful intermediates, present in important synthetic targets. Here, the authors show a strategy for the synthesis of N-aryl aziridines based on...

Arylamines are common structural motifs in pharmaceuticals, natural products, and materials precursors. While olefin aminofunctionalization chemistry can provide entry to arylamines, classical polar...

While X-ray crystallography routinely provides structural characterization of kinetically stable pre-catalysts and intermediates, elucidation of the structures of transient reactive intermediates,...

Development of new electrosynthetic chemistry promises to impact the efficiency and sustainability of organic synthesis. Here we demonstrate that anodically generated hypervalent iodine intermediates...

N-centered nucleophilicity increases upon alkylation, and thus selective partial alkylation of ammonia and primary amines can be challenging: Poor selectivity and overalkylation are often observed....

Synthetic porous materials continue to garner attention as platforms for solid-state chemistry and as designer heterogeneous catalysts. Applications in photochemistry and photocatalysis, however, are...

The development of homogeneous catalysis is enabled by the availability of a rich toolkit of kinetics experiments, such as the Hg-drop test, that differentiate catalytic activity at ligand-supported...

Small molecule redox mediators convey interfacial electron transfer events into bulk solution and can enable diverse substrate activation mechanisms in synthetic electrocatalysis. Here, we report...

The N-activating substituents typically encountered in C–H amination chemistry are challenging to remove and have limited scope for synthetic elaboration. Here, we demonstrate that N-benzylaminopyr...

Characterization of reactive intermediates in C–H functionalization is challenging due to the fleeting lifetimes of these species. Synthetic photochemistry provides a strategy to generate post-turn...

Nature Reviews Chemistry - Here, the utility of nitrogen-atom transfer chemistry is highlighted, the aspects that dictate nitride philicity discussed, and the reactivity of metal nitrides towards...

Four-coordinate transition-metal complexes can adopt a diverse array of coordination geometries, with square planar and tetrahedral coordination being the most prevalent. Previously, we reported the...

ConspectusHypervalent iodine reagents find application as selective chemical oxidants in a diverse array of oxidative transformations. The utility of these reagents is often ascribed to (1) the...

C−H amination chemistry via traceless bifunctional nitrogen activation is reported. Sequential C−H aminopyridylation followed by Ni-catalyzed cross-coupling with aryl boronic acids affords the...

The porosity and synthetic tunability of metal-organic frameworks (MOFs) has motivated interest in application of these materials as designer heterogeneous catalysts. While understanding substrate...

We demonstrate that sequential disproportionation reactions can enable selective aggregation of two- or four electron–holes at a hypervalent iodine center. Disproportionation of an anodically...

C–N bond forming reactions hold immense significance to synthetic organic chemistry. In pursuit of efficient methods for the introduction of nitrogen in organic small molecules, myriad synthetic...

Reticular mechanopolymerization of labile metal nodes and kinetically inert metallomonomers provides a rational synthetic approach to controlling the primary coordination sphere of inert metal nodes...

Temperature-dependent metalation of the new hexadentate ligand (tris(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane; H3TPM) enables the selective synthesis of both mononuclear (i.e. Na(THF)4[Fe(TPM)],...

Methods to incorporate kinetically inert metal nodes and highly basic ligands into single-crystalline metal–organic frameworks (MOFs) are scarce, which prevents synthesis and systematic variation of...

We report the synthesis and oxygen-atom transfer (OAT) photochemistry of [Cu(tpa)BrO3]ClO4. In situ spectroscopy and in crystallo experiments indicate OAT proceeds from a Cu–O fragment generated by...