Moffitt Cancer Center President and CEO,
@MoffittNews
. Tumor immunologist. Inspired leader. Girl dad.
#DocsWhoRock
. Driven to save more lives from
#cancer
.
So many ways for an immune cell to kill (or not to kill) a
#cancer
cell! This is a nice review summarizing non-apoptotic regulated cell death pathways and their complex interactions with the antitumor
#immune
response.
The Hwu Lab mourns the loss of one of our own, Dr. Deb Silverman
@deb_silverman
, who was so courageous in the face of breast cancer at such a young age. I’m so happy Deb was able to receive her Ph.D. and that she could visit from
@MDAndersonNews
to join our last lab team outing.
(1/2) Immune response against
#cancer
can be inhibited by myeloid derived suppressor cells (MDSCs). Defining and studying MDSCs has been challenging due to the lack of specific surface markers.
So sad to hear about the passing of Jeff Weber, a giant in the field of oncology. He was involved in the early days of cytokine and cell therapy and most recently led studies of personalized vaccines for melanoma patients. I originally worked with Jeff
@theNCI
over 30 years ago.
I've officially surpassed my first 100 days
@MoffittNews
and thought it was time to get connected to the world in a new way on Twitter. I'm looking forward to inspiration, collaboration and conversation. More on why I've joined
It’s only appropriate that every few years our anniversary lands on
#Thanksgiving
. Grateful for 32 incredible years together and the best is yet to come! Happy Anniversary to my wife, Katie!
It was an honor to attend The
@WhiteHouse
Holiday Reception last night. We appreciate the commitment and support of
@POTUS
and
@FLOTUS
for cancer prevention, screening and research and to eliminate disparities in
#cancer
outcomes.
#ScienceSaturday
For
#immunotherapy
to be effective, T cells need to effectively infiltrate tumors. In this preclinical study, low molecular weight heparin was found to enhance T cell infiltration and anti-tumor efficacy for both adoptive T cell therapy and immune checkpoint
Happy Father’s Day to all the dads out there! Fatherhood is a humbling and fulfilling role and I have such unconditional love for my two girls who are so creative, compassionate and authentic.
#FathersDay
How it started vs. how it's going! I've learned a lot over the last 50+ years, but the most important lesson is this: Action is what matters. Worrying produces nothing.
#TransformationTuesday
It is such an honor to have
@FLOTUS
Dr. Jill Biden and
@NCIDirector
Dr. Ned Sharpless visiting Moffitt Cancer Center today. We are thrilled to share the important work our teams are doing here
@MoffittNews
to prevent and treat cancer.
I was honored to be officially inducted as a Fellow in the National Academy of Inventors today in Washington, D.C.! The NAI Fellow program has more than 1,700 Fellows worldwide who collectively hold more than 58,000 issued U.S. patents.
@AcadofInventors
Most of you know that our Bichon Frisé, Maisy, was a beloved member of our family. I am sad to share the news that Maisy passed away today, after a long and wonderful 16 years with the Hwu family. We will dearly miss her and the companionship and unconditional love she brought to
Having a wonderful weekend with daughter Emily in Brooklyn, NY. Even got to see her perform with her band. She’s become quite the drummer in less than a year!
#WeekendVibes
This hangs above my desk and is one of my major principles of
#leadership
. It’s by the ancient philosopher Lao Tsu. The best leaders are the ones who elevate others without them even knowing!
#WednesdayWisdom
Dr. Anirban Maitra is a treasured friend and colleague who is a leader in
#pancreaticcancer
research and has served as a mentor to many young investigators throughout the world! Go give him a follow
@Aiims1742
!
#FollowFriday
#ScienceSaturday
How can we identify tumor reactive T cells circulating in the blood? Using single cell transcriptomic profiling of tumor infiltrating lymphocytes (TIL) and blood lymphocytes, researchers at
@NCI_CCR_SB
identified a phenotypic signature of circulating T cells
Saddened by the loss of a member of the
@MoffittNews
family, Dr. Robert Gillies. Bob was a cherished member of the team who made remarkable strides in molecular imaging and cancer research. He will be greatly missed. Our thoughts are with his family, friends and peers.
#ScienceSaturday
CD8+ T cells classically kill tumor cells by recognition of peptide antigens in the context of class I MHC molecules, and downregulation or loss of class I expression can lead to tumor escape.
@EmilyCLerner
et al have now shown that CD8+ T cells can kill class I
Snow Patrol, a Scottish and Irish alternative rock band, had their biggest hit with the release of "Chasing Cars" in 2006. It has since been used in countless movies, TV shows and more. Had a great time covering it with
#TheReMissions
@MoffittNews
last week!
#MusicMonday
🤘
Can you travel from Tampa to NYC and back in the same day? So glad I was able to watch daughter Emily’s band perform in Brooklyn today. She’s become quite the accomplished drummer!
#ScienceSaturday
Mutations in cancer cells look “foreign” to the immune system and are excellent targets for T-cells. However, patients with high levels of mutations in their cancers don’t always respond durably to
#immunotherapy
.
@PeterMKWestcott
,
@LabJacks
et al demonstrate
#ScienceSaturday
Can dietary nutrients help the immune system kill
#cancer
cells? In this study, researchers screened 255 circulating nutrients for the ability to enhance T cell activity and found that the long-chain fatty acid TVA (Trans-vaccenic acid) could enhance the
Who knew that our Chair of Radiation Oncology,
@KOSJ12
, could sing like this?
Fun fact, the piano I’m playing on is the one I grew up playing — it’s over 50 years old!
If you look at the data, it's not the ratio of doctors to patients that's correlated with survival, it's the ratio of nurses to patients. That speaks volumes. I can't thank ours enough for their dedication and commitment to our number one priority, our patients.
#NursesWeek
The future of
#cancer
vaccines is bright! An important consideration is the type of antigen used in the vaccine. This review nicely summarizes the different types of antigens that are being investigated for
#CancerVaccines
.
Everyone knows that we have bacteria in our gut, but did you know that
#cancer
cells can be infected with
#bacteria
and this can suppress the immune response against them?
#ScienceSaturday
The combination of anti-LAG-3 and anti-PD1 antibodies is
@US_FDA
approved for patients with advanced
#melanoma
. But how is this combination working mechanistically? In a recent issue of
@CellCellPress
, 3 manuscripts shed light and suggest that PD-1 blockade
Please join me in welcoming
@karenluMD
to
@MoffittNews
as our new Physician in Chief!
We are grateful to have a nationally recognized physician-scientist of Dr. Lu’s caliber coming onboard to lead our Moffitt Medical Group.
Welcome, Karen Lu, MD (
@karenlumd
), who will join Moffitt as our new Physician in Chief in June.
She has a proven track record of successfully leading clinical and translational teams, and we could not be more excited for her to join Moffitt at such a transformative time.
The Rosenberg group has characterized RNA signatures of T cells in the tumor that recognize cancers. This may help in identifying immune cells and receptors that can be used for patient therapy and will help us understand the tumor immune microenvironment.
Also had the opportunity to meet former pro tennis star
@Martina
Navratilova at the
@RepDWStweets
Cancer Survivorship Summit, who was speaking on The Caregiver Experience.
The Moffitt Cancer Center "M" has officially been hoisted and positioned at the top of our new McKinley hospital. A sure sign of the incredible progress toward our opening this July!
@MoffittNews
Moffitt awarded $10.2 million grant from
@theNCI
to support team research focused on investigating lung cancer metabolism to help develop new therapies. Congrats
@LabElsaFlores
and team!
Honoring and remembering my former student, Dr. Deb Silverman, at
@ACSCAN
's 13th Annual Lights of Hope event in D.C. tonight. Our work continues for the patients of today, the patients of tomorrow and those taken too soon. 🕯💙
#MoffittDCFlyIn
#LightsofHope
@deb_silverman
Behind the scenes filming the band's rooftop music video. And the perfect time to announce our band name (drumroll, please...) "The Remissions!" Now for logo design ... 🤘 🎹 🎤 🎸
As
@SITCancer
President, it was an honor to induct our first class of Fellows of the Academy of Immuno-Oncology (FAIO) last night. These impressive individuals helped get us where we are today, and mentored many of the leaders in the field.
#SITC21
So proud of Ally for her graduation from
@ChapmanU
this weekend! She’s demonstrated such determination and resilience over the past four years!
#ProudDadMoment
Small molecule STING agonists can trigger innate immune cells which can lead to potent T-cell mediated antitumor immune responses.
@NatalieArtzi
and colleagues recently demonstrated that nanoparticle conjugation can enhance the antitumor potency of intravenously administered
Ran into our hard working Environmental Services team preparing for
#HurricaneIan
by removing potential projectiles around campus. Our
@MoffittNews
team is well prepared to weather the storm! Please stay safe.
What an incredible ride it's been at
#SITC23
. It's true, California knows how to party!
#TheCheckPoints
hit the waves tonight for a special "Surfing for a Cure" event. Together, we're riding the tide towards a future without cancer.
@SITCANCER
"What people may not know about me is that I'm an immunologist, and I've had a lab for over 30 years."
Come along for a video tour of
@MoffittNews
president and CEO
@PatrickHwuMD
's lab! 🔬
Congratulations to Dr. Ana Gomes (
@Lab_Gomes
) on receiving the
@NIH
New Innovator Award! This marks the first time a Moffitt faculty member has received this award and demonstrates the exceptional research of Dr. Gomes on aging and cancer development.
👨👩👧👧
#FathersDay
reflections...
So grateful to be a father to my two girls, Emily and Ally. Both bring such bright light to the world around them, and it's so fulfilling to see what compassionate young women they have become. 💕
Happy Father's Day!
Just landed in San Diego! Looking forward to an exciting week at the
@sitcancer
annual meeting and pre-program workshops!
#SITC23
Also excited to be reunited with
#TheCheckPoints
for our West Coast concert on Saturday!
Happy National Doctors’ Day! Thank you to all of our incredible doctors
@MoffittNews
who dedicate so much to our patients and our mission.
#NationalDoctorsDay
Thrilled Moffitt Cancer Center has once again been named the
#1
Cancer Hospital in Florida and the Southeast by
@Newsweek
.
@MoffittNews
has also been recognized on Newsweek’s list of the World's Best Oncology Hospitals. These recognitions are a testament to the quality of
Had the opportunity to show H. Lee Moffitt himself around the Hwu lab
@MoffittNews
. His efforts spearheaded Florida’s first
#cancer
treatment center more than 30 years ago and allowed us to extend world-class cancer care to our state and beyond.
We’re hitting the road from Tampa to Tallahassee for
#MoffittDay
at the Florida State Capitol tomorrow!
Stay tuned to all our
@MoffittNews
social channels for coverage of this important day.
Which patients with recurrent
#glioblastoma
respond to
#immunotherapy
? Activation of the MAPK/ERK pathway in glioblastoma may induce an inflammatory microenvironment that facilitates response to anti-PD1 treatment.
#ScienceSaturday
: T cells recognize and kill
#cancer
often by targeting “neoepitopes,” which are mutations within the tumor cells that are presented on the cell surface within specific HLA molecules. While many of these neoepitopes are specific to individual patients, which ones
One year. 52 weeks. 365 days. 525,600 minutes. We have achieved so much together in my first year
@MoffittNews
, and I’m looking forward to a successful future as we remain steadfast in our mission.
On
#Thanksgiving
and always, I want to share my thanks and gratitude for our team
@MoffittNews
and our colleagues around the globe working together towards a common mission to prevent and cure
#cancer
. On this note, here’s a cover of Dido’s “Thank You,” recorded together with
*New series* In the
#MoffittMedicalMinute
I'll dissect various scientific concepts in just 60 seconds! This week I tackle how the
#COVID19
vaccine works with your immune system.
We congratulate the recipient of the AACR Award for Lifetime Achievement in Cancer Research, Steven A. Rosenberg, MD, PhD, FAACR.
Dr. Rosenberg will present his Award Lecture at
#AACR24
on Saturday, April 6, 3:00-3:45 PM. Learn more:
We recently treated our 1,000th CAR T patient
@MoffittNews
with a comprehensive care team led by Drs. Brandon Blue and Ciara Freeman.
“Treating over 1,000 patients with CART isn’t just about advanced medicine,” says Dr. Freeman. “It’s about fostering hope, pushing boundaries,